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the ideal alpha receptor antagonist should be uroselective with minimal side effects. this prospective study evaluated the efficacy and safety of a new formulation, tamsulosin ocas® (oral controlled absorption system), for luts associated with bph in thai patients. tamsulosin oral controlled absorption system (ocas) in the treatment of benign prostatic hypertrophy. the specific pharmacokinetic properties of tamsulosin ocas® with its efficacy and safety profile in bph patients provided the desirable therapeutic risk benefit ratio.: 10473995 doi: 19996 [pubmed - indexed for medline] sharepublication types, mesh terms, substancespublication typesclinical trialcomparative studymulticenter studyrandomized controlled trialmesh termsadrenergic alpha-1 receptor antagonistsadrenergic alpha-antagonists/adverse effectsadrenergic alpha-antagonists/therapeutic use*ageddrug therapy, combinationejaculation/drug effectserectile dysfunction/drug therapy*erectile dysfunction/epidemiologyerectile dysfunction/etiologyhumansincidencelibido/drug effects*malemiddle agedprostatic hyperplasia/complicationsprostatic hyperplasia/drug therapy*quinazolines/adverse effectsquinazolines/therapeutic usereceptors, adrenergic, alpha-1sulfonamides/adverse effectssulfonamides/therapeutic use*treatment outcomeurethral obstruction/drug therapy*urethral obstruction/etiologysubstancesadra1a protein, humanadrenergic alpha-1 receptor antagonistsadrenergic alpha-antagonistsquinazolinesreceptors, adrenergic, alpha-1sulfonamidesalfuzosintamsulosinlinkout - more resourcesmedicalenlarged prostate (bph) - medlineplus health informationerectile dysfunction - medlineplus health informationmiscellaneousalfuzosin - hazardous substances data banktamsulosin - hazardous substances data bankpubmed commons home.

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the 24-hour sustained efficacy extending over a longer period of time, even at night, leads to improvements in luts/bph, such as nocturia with fewer side effects. the ocas® formulation is a gel matrix comprising gel-forming and gel-enhancing agents (2,3). the exclusion criteria included (1) previous prostatectomy; (2) severe hepatic dysfunction; (3) severe renal dysfunction; (4) severe cardiovascular disorder; (5) orthostatic hypotension; (6) senile dementia; (7) other conditions which can cause voiding dysfunction such as neurogenic bladder, bladder or urethral stone, recurrent urinary tract infection, bladder cancer, prostate cancer, urethral stricture and large bladder diverticulum; (8) history of hypersensitivity or allergy to tamsulosin; (9) symptomatic urinary tract infection in the preceding month (10) nocturnal polyuria; (11) use of 5-alpha-reductase inhibitors within the preceding 3 months; (12) use of diuretics and sleeping pills; (13) use of other pharmacologic treatments for bph, such as alpha blockers or plant extracts in the preceding month; (14) use of medications, such as alpha agonists, cholinergic or anticholinergic drugs, which may influence the pharmacodynamic effects of tamsulosin.% had more than a 1-point decrease in ipss-qol score and, therefore, can be considered responders of the treatment. tamsulosin ocas® (oral controlled absorption system) is a new formulation of tamsulosin which has consistent drug release independent of ph.

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most patients with lower bmi generally tolerate tamsulosin ocas® very well with only few side effects, which are usually mild and all patients tolerated the medication during the treatment period. tamsulosin ocas® rapidly improves luts, both voiding and storage symptoms. cardiovascular safety of the oral controlled absorption system (ocas) formulation of tamsulosin compared to the modified release (mr) formulation. this prospective study evaluated the efficacy and safety of a new formulation, tamsulosin ocas® (oral controlled absorption system), for luts associated with bph in thai patients. ratingspill imagesprecautionsusesbrand namesdrug classside effectsdrug interactionsdrug precautionsfood interactionsinform mdpregnancylactationdrug usagedrug dosageoverdoseother requirements.

tamsulosin oral : Uses, Side Effects, Interactions, Pictures, Warnings

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conclusion: tamsulosin ocas® treatment led to significant improvements in luts, hus and qol in thai patients with bladder outlet obstruction from bph with few side effects. mg tamsulosin ocas®, and were followed up at 2 (visit 3), 4 (visit 4) and 8 (visit 5) weeks post-treatment. garza, pharmd overviews the uses and common side effects of tamsulosinalpha-blockerspharmacist chris adlhaka, pharmd summarizes the uses, common side effects, and warnings for the alpha-blockers class of medications. mg once daily doses of tamsulosin ocas® (harnal ocas®, astellas pharma inc, japan) for a period of 8 weeks. the 24-hour sustained efficacy extending over a longer period of time, even at night, leads to improvements in luts/bph, such as nocturia with fewer side effects.

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most patients with lower bmi generally tolerate tamsulosin ocas® very well with only few side effects, which are usually mild and all patients tolerated the medication during the treatment period. mg once daily doses of tamsulosin ocas® (harnal ocas®, astellas pharma inc, japan) for a period of 8 weeks. the ocas® formulation is a gel matrix comprising gel-forming and gel-enhancing agents (2,3). tamsulosin mr and ocas (modified release and oral controlled absorption system): current therapeutic uses. the advantages of the newer alpha blockers for bph include quick improvement of symptoms and quality of life, and less side effects.

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the specific pharmacokinetic profile of tamsulosin ocas® provides an effective treatment for nocturia and hus with less side effects. tamsulosin ocas® represented a statistically significant 57% improvement in nocturia control (14). the advantages of the newer alpha blockers for bph include quick improvement of symptoms and quality of life, and less side effects. conclusion: tamsulosin ocas® treatment led to significant improvements in luts, hus and qol in thai patients with bladder outlet obstruction from bph with few side effects. mg tamsulosin ocas®, and were followed up at 2 (visit 3), 4 (visit 4) and 8 (visit 5) weeks post-treatment.

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the randomized crossover study concluded that tamsulosin ocas® had a lower incidence of positive stress test than conventional tamsulosin (15). evaluation of primary and secondary outcomes the primary outcome was efficacy of tamsulosin ocas® 0. this 24-hour sustained efficacy of tamsulosin ocas® leads to improvement in luts from bph, such as voiding symptoms and nocturia, with less side effects (2-5). tamsulosin ocas® also improves qol in patients with luts due to boo associated with bph. food interactionsback to topgrapefruit and grapefruit juice may interact with tamsulosin and lead to potentially dangerous effects.

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% had more than a 1-point decrease in ipss-qol score and, therefore, can be considered responders of the treatment. cardiovascular safety of the oral controlled absorption system (ocas) formulation of tamsulosin compared to the modified release (mr) formulation. this study demonstrated the favourable cardiovascular safety profile of tamsulosin ocas® which helped bph patients with cardiovascular co-morbidities and are taking antihypertensive medications. this study demonstrated the favourable cardiovascular safety profile of tamsulosin ocas® which helped bph patients with cardiovascular co-morbidities and are taking antihypertensive medications. urology   the efficacy and safety of oral tamsulosin controlled absorption system (ocas) for the treatment of lower urinary tract symptoms due to bladder outlet obstruction associated with benign prostatic hyperplasia: an open-label preliminary study     bannakij lojanapiwat; sompol permpongkosol division of urology, department of surgery (bl), chiangmai university, chiangmai  and division of urology, department of surgery (sp), ramathibodi hospital, bangkok, thailand correspondence     abstract aims: tamsulosin, a superselective subtype alpha 1a and 1d blocker, is used for the treatment of male lower urinary tract symptoms (luts) commonly caused by benign prostatic hyperplasia (bph).

Tamsulosin Uses, Dosage & Side Effects -

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garza, pharmd overviews the uses and common side effects of tamsulosin. the ideal alpha receptor antagonist should be uroselective with minimal side effects. thus, tamsulosin ocas® has a superior pharmacokinetic profile than conventional tamsulosin, allowing it to deliver consistent drug levels over 24 hours with lower maximum plasma concentration (cmax), irrespective of food intake.  tamsulosin precautionsback to topserious side effects have occurred including:decreased blood pressure when changing positions. the randomized crossover study concluded that tamsulosin ocas® had a lower incidence of positive stress test than conventional tamsulosin (15).

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thus, tamsulosin ocas® has a superior pharmacokinetic profile than conventional tamsulosin, allowing it to deliver consistent drug levels over 24 hours with lower maximum plasma concentration (cmax), irrespective of food intake. - Get up-to-date information on Tamsulosin side effects, uses, dosage, overdose, pregnancy, alcohol and more. tamsulosin ocas® rapidly improves luts, both voiding and storage symptoms. following administration, the tamsulosin ocas® tablet undergoes rapid gelation and complete hydration. side effects may include nausea, vomiting and diarrhea or constipation along with palpitations, fainting or lightheadedness and abnormal ejaculation.

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evaluation of primary and secondary outcomes the primary outcome was efficacy of tamsulosin ocas® 0. tamsulosin ocas® also improves qol in patients with luts due to boo associated with bph. the exclusion criteria included (1) previous prostatectomy; (2) severe hepatic dysfunction; (3) severe renal dysfunction; (4) severe cardiovascular disorder; (5) orthostatic hypotension; (6) senile dementia; (7) other conditions which can cause voiding dysfunction such as neurogenic bladder, bladder or urethral stone, recurrent urinary tract infection, bladder cancer, prostate cancer, urethral stricture and large bladder diverticulum; (8) history of hypersensitivity or allergy to tamsulosin; (9) symptomatic urinary tract infection in the preceding month (10) nocturnal polyuria; (11) use of 5-alpha-reductase inhibitors within the preceding 3 months; (12) use of diuretics and sleeping pills; (13) use of other pharmacologic treatments for bph, such as alpha blockers or plant extracts in the preceding month; (14) use of medications, such as alpha agonists, cholinergic or anticholinergic drugs, which may influence the pharmacodynamic effects of tamsulosin. this 24-hour sustained efficacy of tamsulosin ocas® leads to improvement in luts from bph, such as voiding symptoms and nocturia, with less side effects (2-5). the specific pharmacokinetic properties of tamsulosin ocas® with its efficacy and safety profile in bph patients provided the desirable therapeutic risk benefit ratio.

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